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Semaglutide# Semaglutide is a selective GLP-1 receptor agonist -- a synthetic analog of human GLP-1(7-37) with an Aib substitution at position 8 for DPP-4 resistance and a C18 fatty diacid chain at lysine-26 for albumin binding
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The release of GLP-1 in response to a meal is rapid (within 10 minutes) and highly correlated with the release of insulin and amylin
Their higher starting metabolic rate means the medications thermogenic boost is proportionally smaller
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