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In addition to GLP-1/GIP/GCG receptors tri-agonists, there are also triagonists targeting Xenopus GLP-1/GCG/Cholecystokinin-2 (CCK2) receptors [107], GLP-1/GCG/ neuropeptide Y 2 receptors [108], and GLP-1R, neuropeptide Y1, and neuropeptide Y2 receptors [109]
Obesity is one of the major contributors to female infertility, affecting approximately 2025% of reproductive-age women globally 5 , exerting detrimental effects on reproductive health through endocrine, metabolic, and inflammatory pathways
We highlight emerging strategies - including anti-Mllerian hormone (AMH) neutralization, neuroendocrine modulators, metabolic agents, and next-generation biologics - and discuss the regulatory, ethical, and operational considerations required to accelerate innovation
GLP-1s are not inexpensive, and consumers have a finite budget
Its proven to deliver significant weight loss by acting on GLP-1 and GIP receptors, achieving an average 22.5% body weight reduction over 72 weeks
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