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As a result, targeting a single metabolic pathway may not lead to sustained therapeutic responses, as compensatory mechanisms can activate other pathways, undermining the treatments efficacy

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Nat Cell Biol 2008

however, it is highly recommended to conduct a patch test prior to regular application of skincare products.[4] Users should discontinue use if they experience any signs of allergic reactions, such as redness, hives, or itchiness.[5] While copper can potentially cause skin irritation or toxicity, in vitro studies suggest that GHK-Cu complexes may have a lower likelihood of inducing these effects.[6] However, it is always recommended to consult a healthcare professional before using any new skincare product