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104,105,106 Over a decade ago, an in vitro study revealed that a combination of specific transcription factorsGATA4, MEF2C and TBX5 (collectively referred to as the GMT cocktail)could directly reprogram fibroblasts into functional cardiomyocytes, bypassing the conventional iPSC stage

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Inhibiting it shifts outgoing autonomic and hormonal signals that instruct the liver to adjust glucose production and coordinate peripheral tissues