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It is a naturally occurring molecule at physiological doses

Reference: Japjec M, Horvat Pavlov K, Petrovic A, et al

The second co-stimulatory signal arises from the engagement of B7.1 (CD80) and B7.2 (CD86) molecules on APCsincluding activated macrophages, dendritic cells, and B cellswith CD28 on T cells

It also lowers the chance of bad side effects

New blood vessel formation brings oxygen, nutrients, and immune cells to injured tissues, addressing the fundamental bottleneck in tendon and ligament healing where poor vascularization slows repair

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