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Maturitas 144 , 108111 (2021)
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Several factors likely contribute: the peptide's very short half-life, difficulty crossing the blood-brain barrier in meaningful quantities, small study sizes, differing endpoints (subjective reports versus objective polysomnography), and the placebo-sensitive nature of insomnia outcomes
"As a medical community we are obtaining a better understanding of the physiology and hormones that create and maintain weight gain and this is allowing for improved treatment options of a complex medical condition
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