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In a double-blind placebo-controlled trial, 35 obese women with no history of gallstones or cholecystectomy were treated with a 1,200 calorie per day diet, along with either 11.3 grams per day of omega-3 fats from fish, ursodeoxycholic acid, or placebo for six weeks

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Moreover, the studies by Zhao et al

Monitor for pain, bruising, swelling, warmth, a lump, or worsening irritation, and contact a healthcare professional if anything concerns you