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zerumbet aqueous extract in an OVA-induced BALB/c mice model of anaphylaxis, there was inhibition of inflammatory mediator production and modulation of cytokine gene expression
Comparison across biofluids further highlighted both opportunity and constraint: while lumbar and ventricular CSF showed strong concordance, plasma profiles diverged substantially, particularly for immune-active pathways such as kynurenine metabolism 67 , indicating that treatment-relevant metabolic states are most directly captured in CSF and only partially reflected in peripheral blood
As expected, healthcare systems exhibit substantial cost savings from the use of biosimilars not only due to their reduced price, but also by the consequent fall in the originator anti-TNFs cost [175]
