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Gastrointestinal side effects Some users experience nausea, bloating, diarrhea, or stomach discomfort while taking semaglutide

These drugs work by mimicking the naturally occurring GLP-1 hormone to regulate appetite, increase satiety, reduce calorie intake, and support sustained weight loss in overweight and obese individuals

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In addition, semaglutide (ROR = 1.41, 95% CI = 1.231.63) exhibited a reduced GLP-1 RA-associated psychiatric AE risk compared to dulaglutide (ROR = 1.88, 95% CI = 1.742.04)