In pernicious anemia, the immune system attacks a protein called intrinsic factor, which is required for B12 absorption, and it results in low B12 levels
For Dihexa to progress in Alzheimer's research, several conditions would need to be met: Earlier intervention: Testing in cognitively normal individuals at high risk, or mild cognitive impairment, rather than established dementia Bioavailability optimization: Development of oral formulations with superior brain penetration, or better-tolerated intravenous regimens Combination approaches: Testing Dihexa alongside amyloid-targeting drugs or tau-focused therapeutics Mechanism refinement: Understanding which aspects of HGF signalling are beneficial versus which drive cancer risk concerns Patient stratification: Identifying subgroups (by genetics, biomarker status, disease stage) most likely to respond Dose optimization: The LIFT-AD trial used specific doses
doi:10.1007/s12178-022-09766-3/Published Cabarcas B, Peairs E, Iyer S, et al
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Importantly, no large-scale randomised controlled trials have established MT-II as a safe or effective treatment for ED
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