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The Bottom Line Ipamorelin is a pentapeptide GH secretagogue that activates the GHS-R1a (ghrelin) receptor to release growth hormone without stimulating cortisol, ACTH, or prolactin, a selectivity profile documented at doses 200-fold above its effective GH-releasing dose
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GIPR (Glucose-Dependent Insulinotropic Polypeptide Receptor) Acts synergistically with GLP-1R in dual agonists like Tirzepatide , enhancing insulin sensitivity and fat metabolism for greater metabolic benefits
It should also be noted that lungs and skin are particularly sensitive to oxidative damage
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