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So an important aspect of treating the dysfunction seen in MCAS includes addressing any underlying factors that might be contributing to your immune system burn-out such as: Mold exposure: You can read all about the link between mold and MCAS in my article Mold is a Major Trigger of Mast Activation Cell Syndrome Underlying infections: Hidden infections like Lyme disease, Babesia, Bartonella, or Eppstein Barr can put your mast cells into hyper-drive and contribute to MCAS