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Current understanding is largely based on pharmacovigilance data, clinical trial secondary endpoints, case reports, and small observational studies
Theres probably 50 years of research, and theyve been available for 20 years longer than most people realize, says Rekha Kumar, MD, an endocrinologist and obesity medicine expert at Weill Cornell Medical College and NewYork-Presbyterian Hospital in New York City
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Ideally incorporate rigorous baseline and follow-up assessments: DEXA, body composition, visceral fat, renal function, endocrine panels, inflammatory biomarkers (IL-6, TNF-, SASP markers if available)
This is partially because of an adjustment to your metabolic rate, but largely due to the amount of calories circulating in your system from the fat that is being released
If youre considering taking one of these new weight loss drugs, you have to look at both the upside and the downside
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