The 2.5 mg dose is better called the low-dose starter, because it is the labeled start and now has short direct non-diabetic data behind it. Microdosing has been used for tolerability testing, metabolic-marker support, step-down protocols, and maintenance, not for proven long-term obesity outcomes
Titration: There is generally no need for upward titration with B-complex vitamins as one might do with certain drugs, but if a patient is frail or known to react to injections, the provider may choose to start at a lower dose (for example 0.25-0.5 mL) and then increase to 1 mL as tolerated
Al, obese Zucker rats were received a dose of 500 micrograms/kg of body weight over the course of 19 days
Determination of these values was based on an RDA of 2.4 g/d for non-pregnant women, plus what will be transferred to the fetus during pregnancy and what will be delivered in breast milk
Angle of injection too vertical : As discussed above in detail, the angle of injection may not be severe enough in young children who have very little fat to deal with in order to hit fatty tissue and not muscle
Many body functions require vitamin B12