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In murine anti-CTLA-4 models, butyrate impairs DC maturation and T cell ICOS expression, limiting expansion of tumor-specific and memory T cells and attenuating antitumor efficacy [89]
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For a subset of patients, the same pathways that turn down the urge to overeat may also dampen how rewarding other activities feel, at least for a timeanother reason emotional tone and motivation deserve as much attention between visits as weight and A1c
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