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They are not a substitute for a provider's individualized assessment
The optimal dose for weight loss is 2.4 mg once a week
3 Previous randomized control trials of semaglutide in diabetic and non-diabetic populations have suggested that non-diabetic patients lose more weight than diabetic patients when prescribed semaglutide, but those studies do not represent real-world data and did not evaluate doses lower than 2.4 mg
This happens when significant weight loss leads to loss of facial fat
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Besides GLP-1, DPP-4 also has other substrates and their elevation by DPP-4 inhibition can also contribute to a normalization of glycaemia in type 2 diabetes (indirect target or off-target) (10)
