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Dendritic cell CNS recruitment correlates with disease severity in EAE via CCL2 chemotaxis at the blood-brain barrier through paracellular transmigration and ERK activation

& Hayes, J

Feb 2010;7(2):80-7

Concentrations used in vitro or in animal models vary, but common experimental dosing involves subcutaneous injections in animal studies or topical application in skin models

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250 Although p53 deficiency cannot fully inhibit the formation of inclusions containing mHtt, mice lacking p53 presented a milder disease phenotype through decreased mHtt levels