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Nonalcoholic fatty liver disease, cholesterol gallstones, and cholecystectomy: new insights on a complex relationship
In SUMMIT, tirzepatide reduced the composite of cardiovascular death or worsening heart-failure events by 38% (HR 0.62, 95% CI 0.410.95) and worsening HF events alone by 46% (HR 0.54, 95% CI 0.340.85), with a +6.9-point between-group improvement in the Kansas City Cardiomyopathy Questionnaire Clinical Summary Score (KCCQ-CSS), an 18-meter improvement in 6-minute walk distance (6MWD), and a placebo-adjusted weight loss of 11.6% [5]
Cannabinoid receptors are expressed not only in the brain, but also in the gut and other peripheral organs involved in food intake, metabolism, and energy homeostasis 12,13,14
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It may boost energy levels as it increases the amount of fuel availability that the heart requires to function
Appetite & Energy Balance Hypothalamic MC4R activation has been studied in animal models for its role in feeding suppression, and PT-141 contributes to the published dataset on MC4R-mediated satiety signaling
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