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7,8 Two major factors have limited progress toward investigating the utility of GSH supplementation as a therapeutic strategy in PD
If this is the case, then longitudinal follow-up of patients with initially high GSH levels, should reveal a dynamic lowering of GSH to generate a deficit state over time
A depletion in NAD + results in bioenergetic failure of mitochondria and eventually cell death 90,91
10.1016/j.pneurobio.2010.12.004 273
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