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Some medications (especially certain biologicals or vaccines) require saline or preservative-free water, so always follow the drug manufacturers guidance

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Doses of 2 to 4 times the therapeutic dose have only small effects, but the effect increases rapidly with doses above 8 times the normal therapeutic dose if P-450 activity is elevated

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doi: 10.1002/hep.20183 42 GongS.LanT.ZengL.LuoH.YangX.LiN.et al