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The 2021 STEP 4 trial, published in JAMA, showed that people who continued semaglutide after an initial 20-week run-in kept losing weight, while those who switched to placebo regained nearly 7% of their body weight, confirming that ongoing treatment is key to maintaining results

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Our most recent reportwith data through June 2025showed increases in overall anti-obesity medication (AOM) prescribing and AOM tirzepatide and semaglutide compared to March 2025 ( 1 )

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