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Similar relative bioavailability of semaglutide was shown for IcoSema dosing versus semaglutide dosing alone, as the 90% CI for the ratio of total semaglutide exposure after single dose (AUC 0 t ,SD,Semaglutide ) between IcoSema and semaglutide alone was fully contained within the bioequivalence acceptance interval of [0.80;1.25]
Key Points: Tirzepatide (Zepbound, Mounjaro) causes diarrhea primarily because its GLP-1 component alters how food moves through your entire digestive tract
Lebwohl, M
