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In more rare cases, I will prescribe a low dose of Adderall in the morning in addition to Vyvanse for people who need more of an effect earlier on in the day. Sid Khurana, MD, psychiatrist and cofounder of Nevada Mental Health in Las Vegas, says he also sometimes prescribes Vyvanse and Adderall together but not to be taken together at the same time. He warns that dosing these drugs together increases the risk of adverse events

But two things follow that are worth stating plainly

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The mechanism matters because it often predicts the balance between blood-sugar benefit and weight loss effect