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Signs of SIADH include persistent thirst despite drinking large amounts of water, swelling in the hands or feet, nausea unrelated to the medication timing, confusion or difficulty concentrating, and in severe cases, seizures

Cagrilintide, a long-acting amylin analog, complements this effect by further enhancing fullness and delaying gastric emptying while suppressing glucagon release

It is obesity-specific: six days of long-acting glucagon raised energy expenditure in diet-induced obese mice and had no effect in lean mice

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