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Transdermal-delivery research has repeatedly demonstrated that microneedle-created channels can increase the skin permeation of hydrophilic and larger molecules by many-fold compared with application to intact skin the exact magnitude depends on needle length, density, molecule size, and how soon after treatment the active is applied

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doi: 10.1006/pmpp.1999.0231 197 LogemannE.HahlbrockK

PMC 3186286

Rheumatology, 40(12), 1317-1325

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