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Studies suggest fasting increases natural GLP-1 secretion, enhancing insulin sensitivity and promoting fat loss
Tirzepatide is indicated an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial BMI of 30 (obesity) or 27 (overweight) in the presence of at least one weight-related comorbid condition (eg, hypertension, dyslipidemia, T2D, obstructive sleep apnea, or CVD)
However, mood changes are not officially recognised as a side effect in the MHRA-approved product literature
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However, it is unsuitable for patients with a family history of specific thyroid carcinomas or Multiple Endocrine Neoplasia syndrome type 2