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cDNA microarray analysis of rat Achilles tendon fibroblasts identified the growth hormone receptor as one of the most abundantly up-regulated genes following exposure to the peptide, with concentration- and time-dependent increases confirmed at both mRNA and protein level, and downstream Janus kinase 2 activation observed on subsequent growth hormone stimulation [3]
It enhances growth hormone receptor expression and several pathways involved in cell growth and angiogenesis, and increases nitric oxide production by upregulating nitric oxide synthase (NOS) gene and protein expression
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It mimics the incretin hormone GLP-1, which stimulates insulin secretion, suppresses glucagon release, and reduces appetite through central nervous system signaling
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