ChaC1 and ChaC2 use the -amine of L-glutamyl residues to cleave the amide bond by transamination, releasing it as a cyclic 5-oxo-l-proline and cysteine glycine dipeptide
While subcutaneous injection anywhere provides systemic benefits, injecting in the abdominal area near the scalp or using microneedling with topical GHK-Cu delivers peptide directly where hair follicles need it
PMID 15990954
The excessive cytosolic calcium activates apoptotic proteins such as calpain, calcineurin, and caspases, ultimately leading to cell death (Folkerts, Parks, Dedman, Kaetzel, Lyeth and Berman, 2007
The balance between these two types of melanin determines an individuals unique skin tone
Studies examine the optimal timing, ratios, and dosing strategies for maximum synergy