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AOD 9604 had no effect on serum IGF-1 levels at any dose tested

Connexin hemichannel blockade is neuroprotective after, but not during, global cerebral ischemia in near-term fetal sheep

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Their headline weight-loss figures are similar (about 20.4% for CagriSema in REDEFINE 1 and about 20.9% for tirzepatide 15 mg in SURMOUNT-1), but those come from separate trials in different populations over different durations

Ashley emerged as the most evidence-aligned overall , Dean occupied a more scientific but still overstated middle ground, and Trevor showed the biggest gap between confidence, salesmanship and actual human evidence