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Gastrointestinal side effects are the most common early experiences, affecting 3050% of patients to varying degrees

doi: 10.1186/s40104-018-0298-1 7 AlkhashabA

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The endocrine and metabolic adaptation observed in both models may be a strategy to increase life span through a slower cell growing/metabolism, a slower loss of physiologic reserve capacity, a shift of cellular metabolism from cell proliferation to repair activities and a decrease in accumulation of senescent cells

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Sonia Hernandez-Diaz, senior author of the report published in Annals of Internal Medicine