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Furthermore, studies have shown that following the consumption of ellagitannin-rich pomegranate extract, high concentrations of UA are detected in the prostate, gut, and colon of prostate cancer model mice, whereas elevated levels of UA-sulfate and UA-glucuronide are detected in the liver and kidneys (29)

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Polysome profiling Cells were lysed in 500 L polysome lysis buffer (25 mM HEPES pH 7.5, 5 mM MgCl 2 , 0.1 M KCl, 2 mM DTT, 1% Triton-X, 0.1 mg/mL cycloheximide) and incubated on ice for 5 min

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It is possible that these variants have impaired folding and localisation, although R169W has previously been shown to localise normally to the membrane 53

The 10-year incidence of glaucoma among patients with treated and untreated ocular hypertension