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doi: 10.1093/humrep/dez243 217 Martn-RomeroFJMiguel-LasobrasEMDomnguez-ArroyoJAGonzlez-CarreraElvarezIS

Some researchers have shown that metformin activates AMPK and triggers the downstream GSH system to slow DOX-mediated oxidative impairment in the myocardium [225, 226]

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In one of these studies, measuring brain GSH levels with in vivo proton MRS yielded a correlation in GSH reduction and decline in cognitive functions with 87.5% sensitivity and 100% specificity (Mandal et al., 2015)