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Beyond energy production, NAD+ also supports several important biological processes including: Activating longevity pathways called sirtuins Supporting DNA repair mechanisms Improving mitochondrial function Helping regulate metabolic health Unfortunately, NAD+ levels naturally decline as we age

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Vitamin B12 enhances these effects by contributing to the production of red blood cells and improving oxygen delivery throughout the body, which supports endurance and energy expenditure

For example, in one study in postmenopausal women, 600 mg of NAC daily improved various markers of immune function and oxidative stress

These studies suggested GSTM2 regulated lipid metabolism specially beyond detoxification/antioxidant, the basic functions of GSTs