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The study compared outcomes in those taking GLP-1 RAs versus DPP-4 inhibitors, revealing promising findings: Among 25,838 SLE patients, those on GLP-1 RAs had significantly fewer major cardiac events, such as heart attacks and strokes, compared to those on DPP-4 inhibitors
This is a significant phenotype, as a similar reduction in circulating triglycerides was not observed with a liver-specific loss of critical lipogenic enzymes, such as fatty acid synthase (FASN) 81
Asada et al
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