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If a patient fails to achieve desired results on tirzepatide monotherapy after adequate dose optimization, the appropriate next stepas supported by clinical guidelinesis to discontinue tirzepatide and switch to a different class of weight-loss medication (such as an orlistat or a future non-GLP-1 agent), not to add semaglutide

In fact, the same GLP-1 pathway causing loose stools is responsible for appetite suppression and weight loss

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10.1046/j.1365-2796.1996.377740000.x 115 SmithE

You can read the full article at Triple Reuptake Inhibitors: The Next Generation of Antidepressants Since the 1960s, most antidepressant drugs have focused on increasing the levels of certain chemicals in the brain called monoamines