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Among these, 15 patients developed T2DM prior to PD diagnosis (71.4%) with a median of 4 years [interquartile range (IQR), 5], while the remaining six developed T2DM after PD onset (28.6%) with a median of 3.5 years (IQR, 4)

This pattern could be influenced by factors such as medication adherence and physiological adaptation

This raises questions as to whether obesity medications may need to be used long term

However, even in people without diabetes, optimising natural GLP-1 production may support metabolic health, potentially reduce appetite, and possibly contribute to maintaining insulin sensitivity

GHRP-2 reliably elevates plasma ACTH and cortisol in both rodent models and the early human pharmacology studies from the 1990s

Stutsman and C