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Acknowledgements Graphical Abstract, Figure 1, and Figure 2 were created using Biorender

The STEP clinical trials the largest studies ever conducted on semaglutide, found that nausea typically resolves within the first two weeks, diarrhea clears within days, and even constipation, the most persistent GI side effect, averages around 47 days before it improves

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This infographic provides a breakdown of considerations that apply to each investigation approach.