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This atrophy can make walking on hard surfaces painful and increase the risk of developing pressure-related injuries

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Additionally, the majority of studies did not report adverse events stratified by age within adults, thus preventing subgroup analyses comparing adult and elderly subjects

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doi:10.1016/S0140-6736(17)30703-1 [5] Bharucha AE, Pemberton JH, Loke GR

These questions represent the frontier of knowledge, and the answers, when they come, will refine the prevention and treatment strategies outlined in this guide