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273 Moreover, GLP-1RAs could decelerate the progression of OA and mitigate pathological damage in a rat OA model

In animal models, use of the choline TMA lyase inhibitor iodomethyl choline (IMC) increases bacterial cholesterol metabolite loss and decreases intestinal sterol transport protein Niemann-Pick C1-Like 1 (NPC1L1) expression, reshaping gut microbiota and reducing hepatic cholesterol accumulation, while upregulating CYP7A1 and other bile acid-related genes (Pathak et al., 2020)

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Patients allege they were never warned of a potential association between Ozempic and other GLP-1 drugs , rapid metabolic or blood pressure changes, and optic nerve injury, despite emerging reports and post-marketing safety signals

It mimics the natural effects of GLP-1 to reduce appetite, slow digestion, and increase satiety, making it easier to eat less and lose weight