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Further exploration of the mechanism of action of FTO in UM cells revealed that high expression of FTO can reduce the m 6 A level within cells, thereby affecting the expression and function of a series of downstream genes
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Equally important is the hit on the selenoprotein thioredoxin reductase 1 (TXNRD1), which also was highly scored by both NetCorona and PROSPER (Figure 2E)
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