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Chronic esophagitis produces thinning of the protective epithelial layer, increasing vulnerability to further acid injury
When treated with 5FU, cancer cells specifically increase mitochondrial content to buffer nucleotide stress, whereas stromal cells do not, meaning that cancer cells become intrinsically more dependent on mitochondrial metabolism
That is strong clinical evidence
You cant treat the root cause of histamine issues when you have a histamine problem
Excited for this as it pushes boundaries
The FDA label and Phase III trials both start patients at the full dose on day one
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