Never increase more than 100mcg at a time, and allow at least one week at each dose before further adjustment
Repeated dosing studies in rats, dogs, and mice for up to 6 weeks across doses from 0.006 mg/kg to 20 mg/kg via multiple routes showed excellent tolerance
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Peptides can interact through disulfide bond formation, aggregation, or pH-mediated precipitation, particularly when mixing sequences with differing isoelectric points
This is also more common for hydroxocobalamin, a form that is used less commonly in veterinary medicine
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