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Recent studies showed that butyrate supplementation reduced serum triglyceride levels and the respiratory exchange ratio in high-fat diet (HFD)-fed animals compared to controls with HFD only, suggesting that butyrate may exert its effect by promoting fatty acid oxidation ( Although butyrate mechanisms of action are unclear, previous studies show that butyrate modulates the AMP/ATP ratio activating the AMPK pathway to promote oxidative metabolism (decrease lipid synthesis and increase lipid oxidation) in the liver and adipose tissue ( Butyrate as a regulator of body weight In addition to its well-known effects on intestine function ( via gavage ( Although there is evidence that sodium butyrate supplementation in standard diet-fed rats reduced weight gain (Table 1
Armstrong JS, Jones DP
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These mechanisms, however, appear to be different than the means by which LPS and systemic inflammation increase paracellular permeability and should not be interpreted as equivalent
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