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Release of highly cytotoxic components of NETs can directly damage adjacent renal TECs, exacerbating endothelial dysfunction, podocyte damage, and fibrotic remodeling (219)

Moreover, RIPK3 expression exhibits spatiotemporal heterogeneity [56]

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Patients losing substantial weight should have their dosing reviewed if they approach this threshold, particularly if they also meet one of the other criteria (age 80 years or serum creatinine 133 micromol/L)

The GLP-1 receptor agonist liraglutide protects against oxidized LDL-induced endothelial inflammation and dysfunction via KLF2

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