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Thus dosage, pharmacokinetics, long-term safety, off-target effects in humans remain unknown

I'm going to put up a tweet every week with you tagged until this list is published online

2.3 Study selection and data extraction After completing the initial database searches, all retrieved records were screened by title and abstract to identify potentially relevant studies, followed by a full-text review to determine final eligibility based on the predefined inclusion and exclusion criteria

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Intoxications over the 450 line (green line below): third dose of 18.75 mg/kg/hr (triple the standard dose)

A complicating factor in clinical trials has been the significant inter-individual variability in susceptibility to APAP toxicity 14