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Clone with a Q45R substitution showed the best activity and was named G2 (Supplementary Fig

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Clinical evidence for oral glutathione and skin lightening exists, including a randomized controlled trial that found 250 mg/day significantly reduced melanin index after four weeks of administration

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Several HDT drugs used in the treatment of TB, including statins, macrocyclic lactones, and TKI, have received approval by the US Food and Drug Administration for other clinical applications, underscoring their favorable safety profiles