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The diabetic environment often results in impaired wound healing processes for DFU, mainly attributed to excess oxidative stimulation, prolonged inflammation, dysfunction of immune cells, delayed reinnervation, and reduced angiogenesis at the wound site [113, 114]
doi: 10.1111/j.1749-6632.1990.tb00140.x 44 TaylorEW
Its history is best read not as a single discovery event but as the endpoint of roughly two decades of medicinal chemistry that began with an accidental observation about opioid analogs and ended with a compound engineered for receptor selectivity
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Morphological alterations, including increased spherocytes and stomatocytes, were evident in smokers, particularly HS
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