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Research director Markku Lahteenvuo, from the University of Eastern Finland, said: Because this is a registry-based study, we cannot determine exactly why or how these medications affect mood symptoms, but the association was quite strong

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"(r)-, but not (s)-alpha lipoic acid stimulates deficient brain pyruvate dehydrogenase complex in vascular dementia, but not in Alzheimer dementia"

Experimental studies provide strong evidence that insulin resistance-related neuroinflammation feeds cognitive impairment neuropathology, leading to a raised-up brain levels of pro-inflammatory cytokines (Mullins et al., 2017