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For instance, doxorubicin can increase H 2 O 2 /O/OH generation, induce ICD, and activate antitumor responses

Studies in older mice investigating individual cells as well as larger vessels and micro-vessels will be useful in determining which cells of the cerebrovasculature are responsible for these changes and whether there are APOE -driven differences in FAO in both larger and smaller vessels that can affect transport functions

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