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Presented for research literature review only Lin YH et al
The FDA approved Mounjaro for type 2 diabetes in May 2022 and for chronic weight management (as Zepbound, same molecule) in November 2023
Also at higher doses, it acts on centers in the brain and suppresses appetite
Metabolomics of gWAT revealed that NDI1 expression led to an increase in abundance of several nucleotides (NAD + , ATP, GTP) and succinic acid, a reduction in pyruvic acid and -ketoglutarate, and an increase in the NAD + -to-NADH and ATP-to-ADP ratios (Fig
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This is one mechanism behind its blood sugar lowering effects, and it operates through a pathway largely independent of insulin receptor signaling
